Polymer-drug and polymer-protein conjugated nanocarriers: Design, drug delivery, imaging, therapy, and clinical applications.
Wiley Interdiscip Rev Nanomed Nanobiotechnol
; 16(4): e1988, 2024.
Article
em En
| MEDLINE
| ID: mdl-39109479
ABSTRACT
Polymer-drug conjugates and polymer-protein conjugates have been pivotal in the realm of drug delivery systems for over half a century. These polymeric drugs are characterized by the conjugation of therapeutic molecules or functional moieties to polymers, enabling a range of benefits including extended circulation times, targeted delivery, controlled release, and decreased immunogenicity. This review delves into recent advancements and challenges in the clinical translations and preclinical studies of polymer-drug conjugates and polymer-protein conjugates. The design principles and functionalization strategies crucial for the development of these polymeric drugs were explored followed by the review of structural properties and characteristics of various polymer carriers. This review also identifies significant obstacles in the clinical translation of polymer-drug conjugates and provides insights into the directions for their future development. This article is categorized under Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Portadores de Fármacos
/
Proteínas
/
Sistemas de Liberação de Medicamentos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Wiley Interdiscip Rev Nanomed Nanobiotechnol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China