Synthetic biology toolkit of Ralstonia eutropha (Cupriavidus necator).
Appl Microbiol Biotechnol
; 108(1): 450, 2024 Aug 29.
Article
em En
| MEDLINE
| ID: mdl-39207499
ABSTRACT
Synthetic biology encompasses many kinds of ideas and techniques with the common theme of creating something novel. The industrially relevant microorganism, Ralstonia eutropha (also known as Cupriavidus necator), has long been a subject of metabolic engineering efforts to either enhance a product it naturally makes (polyhydroxyalkanoate) or produce novel bioproducts (e.g., biofuels and other small molecule compounds). Given the metabolic versatility of R. eutropha and the existence of multiple molecular genetic tools and techniques for the organism, development of a synthetic biology toolkit is underway. This toolkit will allow for novel, user-friendly design that can impart new capabilities to R. eutropha strains to be used for novel application. This article reviews the different synthetic biology techniques currently available for modifying and enhancing bioproduction in R. eutropha. KEY POINTS ⢠R. eutropha (C. necator) is a versatile organism that has been examined for many applications. ⢠Synthetic biology is being used to design more powerful strains for bioproduction. ⢠A diverse synthetic biology toolkit is being developed to enhance R. eutropha's capabilities.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cupriavidus necator
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Biologia Sintética
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Engenharia Metabólica
Idioma:
En
Revista:
Appl Microbiol Biotechnol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Alemanha