The effect of perineural dexamethasone on nerve injury and recovery of nerve function after surgery: A randomized controlled trial.
Heliyon
; 10(16): e35612, 2024 Aug 30.
Article
em En
| MEDLINE
| ID: mdl-39220966
ABSTRACT
Background:
While numerous studies have examined the influence of perineural dexamethasone on nerve block duration, its potential impact on postoperative nerve injury has not been adequately addressed.Objective:
This study aims to elucidate the effect of perineural dexamethasone on nerve injury and nerve function recovery after surgery.Design:
A prospective randomized double-blinded trial.Setting:
The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. The study was conducted between 14 June and 30 December 2022.Participants:
Patients aged 18 - 80 years, ASA I - II, scheduled for elective orthopedic or burn and plastic surgery.Interventions:
Patients were randomized to receive either perineural dexamethasone (D group) or no dexamethasone (ND group). Main outcomemeasures:
Primary outcomes were the incidence and recovery of nerve injury. Secondary outcomes included postoperative pain scores, analgesic consumption, and adverse events.Results:
Initial postoperative nerve injury rates were similar between groups (D 30.4 %, ND 33.3 %, P > 0.05). At 12 weeks post-discharge, significantly more patients in the ND group recovered from nerve deficits (78.8 % vs 60.3 %; OR = 2.45, 95 % CI = 1.05 - 5.72, P < 0.05). No significant differences were observed in postoperative hyperglycemia or surgical site infection rates.Conclusion:
Perineural dexamethasone may impede nerve function recovery, suggesting caution in its use, particularly for patients with pre-existing nerve damage or diabetes. Further research is needed to elucidate the long-term effects of dexamethasone on nerve tissue recovery. Trial registration chictr.org.cn, ChiCTR2200059424.
Texto completo:
1
Base de dados:
MEDLINE
Idioma:
En
Revista:
Heliyon
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China