Inhibition of gluconeogenesis by 2,5-anhydro-D-mannitol in isolated rat hepatocytes.
Biochim Biophys Acta
; 845(3): 502-6, 1985 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-3924119
ABSTRACT
2,5-Anhydro-D-mannitol inhibited glucose synthesis, increased the pyruvate/phosphoenolpyruvate ratio and altered adenine nucleotide concentrations in hepatocytes isolated from fasted rats. The accumulations of 2,5-anhydro-D-mannitol 1,6-diphosphate, an allosteric activator of pyruvate kinase, and of ADP in treated hepatocytes can account for the increase in pyruvate/phosphoenolpyruvate ratio and the inhibition of glucose synthesis from lactate.
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Base de dados:
MEDLINE
Assunto principal:
Gluconeogênese
/
Fígado
/
Manitol
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1985
Tipo de documento:
Article