Interaction of xylamine with peripheral sympathetic neurons.
Life Sci
; 37(13): 1177-82, 1985 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-3930904
ABSTRACT
Xylamine (XYL) administered to intact rats caused a 70-80% reduction in norepinephrine (NE) uptake by the vas deferens but had little or no effect on NE content in that tissue. The vas deferens accumulates 3H-XYL in vitro by a desmethylimipramine (DMI)-sensitive mechanism. Vasa deferentia from 6-hydroxydopamine (6OHDA) pretreated animals exhibited a 80% reduction in both NE content and XYL uptake activity. These results indicate that XYL is taken up by sympathetic nerve terminals and can reduce NE uptake activity without depleting terminals of neurotransmitter.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Simpático
/
Neurônios
/
Compostos de Mostarda Nitrogenada
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
1985
Tipo de documento:
Article