Adrenal-mediated endogenous metabolites inhibit puberty in female mice.
Science
; 231(4739): 722-5, 1986 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-3945805
ABSTRACT
While assessing a potential role of adrenal glands in the production of the hitherto unidentified puberty-delaying pheromone of female mice, the urinary volatile profiles of normal and adrenalectomized animals were quantitatively compared. Six components, whose concentrations were depressed after adrenalectomy, were identified 2-heptanone, trans-5-hepten-2-one, trans-4-hepten-2-one, n-pentyl acetate, cis-2-penten-1-yl acetate, and 2,5-dimethylpyrazine. When these laboratory-synthesized chemicals were added (in their natural concentrations) to either previously inactive urine from adrenalectomized females or plain water, the biological activity was fully restored.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Maturidade Sexual
/
Glândulas Suprarrenais
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
1986
Tipo de documento:
Article