2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) promotes the transformation of C3H/10T1/2 cells.
Carcinogenesis
; 6(4): 651-3, 1985 Apr.
Article
em En
| MEDLINE
| ID: mdl-3986969
ABSTRACT
Continuous treatment of C3H/10T1/2 cells with low concentrations (greater than or equal to 4 pM) of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) enhanced focus production in cultures pretreated with N-methyl-N'-nitro-N-nitrosoguanidine. Maximal enhancement occurred at 40 pM TCDD, a concentration 10 000-fold lower than that required to produce an optimal response with 12-O-tetradecanoylphorbol-13-acetate. Single treatments with 0.06 nM-5 microM TCDD did not transform C3H/10T1/2 cells or initiate the process of transformation in cultures subsequently exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Promotion of transformation is thus the predominant effect of TCDD in the C3H/101/2 cell transformation system.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Transformação Celular Neoplásica
/
Dioxinas
/
Dibenzodioxinas Policloradas
Limite:
Animals
Idioma:
En
Revista:
Carcinogenesis
Ano de publicação:
1985
Tipo de documento:
Article