Low molecular weight heparin in haemodialysis and haemofiltration--comparison with unfractioned heparin.
Proc Eur Dial Transplant Assoc Eur Ren Assoc
; 21: 276-80, 1985.
Article
em En
| MEDLINE
| ID: mdl-3991511
ABSTRACT
The low molecular weight heparin CY 222 (CHOAY) has been compared to unfractioned heparin (UFH) in patients on chronic haemodialysis and haemofiltration at various doses as regards it biological activity (measured by Activated Partial Thromboplastin Time and by anti-Xa activity) and its clinical effect on clot formation in the blood lines and bleeding at the puncture sites or recent wounds. Compared to UFH, CY 222 has a greater anti-Xa activity for a shorter APTT. This biological difference is of clinical advantage since clotting in lines is comparable or less than with UFH whereas compression time at puncture sites is shorter and recently bleeding wounds in 28 patients did not bleed again. The long half life of CY 222 allows its use as a single priming dose of 300 anti-Xa U/kg in haemodialysis and 450 anti-Xa U/kg in haemofiltration.
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Base de dados:
MEDLINE
Assunto principal:
Heparina
/
Diálise Renal
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Proc Eur Dial Transplant Assoc Eur Ren Assoc
Assunto da revista:
NEFROLOGIA
/
TRANSPLANTE
Ano de publicação:
1985
Tipo de documento:
Article