Inhibition of hyphal development in Trichophyton mentagrophytes arthroconidia by ketoconazole and miconazole.
J Antimicrob Chemother
; 15(4): 405-15, 1985 Apr.
Article
em En
| MEDLINE
| ID: mdl-4008375
ABSTRACT
In the presence of 0.5 mg/l ketoconazole and miconazole, arthroconidia from three isolates of Trichophyton mentagrophytes produced germ tubes, which continued to grow for 12 h before further elongation ceased. Lower concentrations reduced the rate of elongation, but did not halt the process. Higher concentrations had no greater effect than 0.5 mg/l. The inhibitory effect of ketoconazole was independent of time of addition of drug during the first six hours of germination. Ketoconazole inhibition was reversible after 12 h contact, whereas miconazole inhibition was not. Morphological effects of drug treatment were investigated by scanning electron microscopy. In the absence of imidazoles, hyphae were straight and regular; ketoconazole treated hyphae were short, irregular and branching; miconazole treatment produced extensive debris and spores forming within the hyphae were visible.
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Base de dados:
MEDLINE
Assunto principal:
Trichophyton
/
Cetoconazol
/
Miconazol
Idioma:
En
Revista:
J Antimicrob Chemother
Ano de publicação:
1985
Tipo de documento:
Article