Staphylococci, in vitro and in vivo.
Diagn Microbiol Infect Dis
; 3(5): 433-44, 1985 Sep.
Article
em En
| MEDLINE
| ID: mdl-4028668
ABSTRACT
Strains of Staphylococcus aureus were grown in broth and by the membrane technique; both drug-free media and media containing cloxacillin were used. The staphylococci grown in broth containing cloxacillin showed one thick cross wall and were larger than those grown in drug-free broth 1.6 micron in diameter as opposed to 0.9 micron. The staphylococci grown on membranes placed on agar containing cloxacillin were 2-3 microns in diameter and contained three or more cross walls. Mice were infected intraperitoneally with staphylococci. After treatment with cloxacillin, the peritoneal fluid and spleens contained staphylococci that were 2-3 microns in diameter with three or more cross walls. A staphylococcal endocarditis was induced in rabbits that were then treated with cloxacillin. The staphylococci in the vegetation of the treated rabbits were 2-3 microns in diameter and contained multiple cross walls. Large staphylococci with multiple cross walls were observed in specimens from patients with respiratory infections treated with beta-lactam antibiotics. It appears, therefore, that the ultrastructure of staphylococci in vivo is comparable to that of staphylococci grown on a solid support medium such as a membrane, and different from that of staphylococci grown in a liquid medium.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Estafilocócicas
/
Staphylococcus aureus
/
Cloxacilina
Limite:
Animals
Idioma:
En
Revista:
Diagn Microbiol Infect Dis
Ano de publicação:
1985
Tipo de documento:
Article