Decreased antigenicity of mouse blastocysts after activation for implantation from experimental delay.
Transplantation
; 19(6): 479-84, 1975 Jun.
Article
em En
| MEDLINE
| ID: mdl-49109
ABSTRACT
The antigenicity of mouse blastocysts in experimentally delayed implantation and after activation from delay by estradiol administration were determined by two different methods. CBA blastocysts were incubated in C57BL/6J anti-CBA serum, and the amount of antibodies bound to the blastocysts was traced by -125-I-conjugated sheep antimouse gamma-globulin (isotope antiglobulin technique) and sensitized sheep red cells (mixed haemadsorption technique). With both techniques it was possible to demonstrate that mouse blastocysts in experimental delay of implantation possess alloantigens, and that this antigen expression has decreased markedly 14 hr after activation for implantation. It is suggested that this phenomenon may be of significance for noncognition of the allogeneic conceptus during pregnancy.
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Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Implantação Tardia do Embrião
/
Blastocisto
/
Epitopos
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Transplantation
Ano de publicação:
1975
Tipo de documento:
Article