The metabolism of isamoxole in the rat and guinea-pig.
Xenobiotica
; 9(10): 585-94, 1979 Oct.
Article
em En
| MEDLINE
| ID: mdl-532211
ABSTRACT
1. The absorption, metabolism and excretion of isamoxole, (2-methyl-N-butyl-N-(4-methyloxazol-2-yl)propanamide), a compound with anti-allergy properties, has been studied in the rat and guinea-pig. 2. The compound was well-absorbed by both species after oral doses of 50 to 150 mg/kg. It underwent extensive first-pass metabolism in the liver, and was excreted as a mixture of metabolites, predominantly in the urine, within 48 h. 3. Three major routes of metabolism were involved, namely deacylation, oxidative ring scission and alkyl oxidation. 4. A major plasma and urine metabolite was 1-butyl-3-(1-carboxyethyl)urea, and this was accompanied by low levels of its cyclized product 3-butyl-5-methylhydantoin.
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Base de dados:
MEDLINE
Assunto principal:
Oxazóis
Limite:
Animals
Idioma:
En
Revista:
Xenobiotica
Ano de publicação:
1979
Tipo de documento:
Article