Circadian periodicity of tryptophan metabolism.
J Clin Invest
; 47(4): 934-9, 1968 Apr.
Article
em En
| MEDLINE
| ID: mdl-5641628
ABSTRACT
Rhythmicity of tryptophan metabolism via the kynurenine pathway has been demonstrated in man. Normal subjects given 3 g of tryptophan at 0900 hours excreted almost three times the quantity of kynurenine, kynurenic acid, and xanthurenic acid than did subjects given the same dose at 2100 hours. Other metabolites of the kynurenine pathway varied in the same fashion but with lesser magnitude. In contrast, indican, a tryptophan metabolite not in the kynurenine pathway, varied inversely with the other metabolites measured. The data suggest that the liver enzyme tryptophan pyrrolase has a circadian rhythm in man similar to that already described in mice in a previous study. Tryptophan tolerance tests in the future should be controlled relative to time of amino acid administration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triptofano
/
Ritmo Circadiano
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
1968
Tipo de documento:
Article