Antibody to acetylcholine receptor in canine and human myasthenia gravis: differential cross-reactivity with human and rabbit receptor.
Neurology
; 29(7): 1065-8, 1979 Jul.
Article
em En
| MEDLINE
| ID: mdl-572937
ABSTRACT
Anti-acetylcholine receptor (AChR) antibody (ab) was found in the serum of a dog with acute myasthenia gravis (MG) by the use of Cowan 1 strain Staphylococcus aureus to bind radiolabeled anti-AChR ab-AChR immune complexes. Fifteen months later, when the dog was in remission, there was only a very low level of the anti-AChR ab. These observations strengthen the contention that anti-AChR ab is important in the pathophysiology of myasthenia gravis. Higher titers of the canine ab were measured with rabbit than with human AChR, whereas 17 human MG sera, selected to represent a wide range of anti-AChR ab titers, were all more reactive with human AChR. The degree of cross-reactivity of human anti-AChR ab with rabbit AChR varied widely, indicating a heterogeneous population of anti-AChR ab molecules in human myasthenia gravis sera.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Receptores Colinérgicos
/
Doenças do Cão
/
Miastenia Gravis
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurology
Ano de publicação:
1979
Tipo de documento:
Article