Retinoic acid and steroids inhibit Epstein-Barr virus-induced nuclear antigen, DNA synthesis and lymphocyte transformation.
Anticancer Res
; 4(6): 415-8, 1984.
Article
em En
| MEDLINE
| ID: mdl-6097161
ABSTRACT
Retinoic acid, dexamethasone and prednisolone were evaluated for their effects on Epstein-Barr virus (EBV)-induced nuclear antigen (EBNA), DNA synthesis and transformation of human thymus-independent, B lymphocytes. It was found that continuous treatment of target cells with these agents completely inhibited EBV-induced transformation events. However, discontinuous treatment of the virus-infected cultures with these agents resulted in the recovery of DNA synthesis, and the appearance of EBNA and transformation. When the cells were treated with these agents 8 days after the virus infection, the inhibitors had no effect. These results show that only continuous treatment with these agents inhibited EBV-mediated transformation; these inhibitors had no effect once the EBNA and EBV-induced DNA synthesis were initiated in target lymphocytes.
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Base de dados:
MEDLINE
Assunto principal:
Esteroides
/
Tretinoína
/
DNA
/
Transformação Celular Viral
/
Herpesvirus Humano 4
/
Antígenos Virais
Limite:
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
1984
Tipo de documento:
Article