An improved method for the estimation of suramin in plasma and trypanosome samples.
Mol Biochem Parasitol
; 1(6): 307-13, 1980 Oct.
Article
em En
| MEDLINE
| ID: mdl-6108509
An improved method for the chemical estimation of suramin is described in which the aromatic amines released from the drug by acid hydrolysis are diazotised and then coupled to N-(1-naphthyl)-ethylenediamine to form a pink coloured product (EmM545nm267 /+- 5) Provided certain precautions are followed, the assay method is highly reproducible (+/- 2%) and sufficiently sensitive to measure 2.5 nmol; suramin in mixtures with plasma (0.5 ml) or trypanosomes (200 mg wet wt.).
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Base de dados:
MEDLINE
Assunto principal:
Suramina
/
Trypanosoma brucei brucei
/
Tripanossomíase Africana
Limite:
Animals
Idioma:
En
Revista:
Mol Biochem Parasitol
Ano de publicação:
1980
Tipo de documento:
Article