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An improved method for the estimation of suramin in plasma and trypanosome samples.
Mol Biochem Parasitol ; 1(6): 307-13, 1980 Oct.
Article em En | MEDLINE | ID: mdl-6108509
An improved method for the chemical estimation of suramin is described in which the aromatic amines released from the drug by acid hydrolysis are diazotised and then coupled to N-(1-naphthyl)-ethylenediamine to form a pink coloured product (EmM545nm267 /+- 5) Provided certain precautions are followed, the assay method is highly reproducible (+/- 2%) and sufficiently sensitive to measure 2.5 nmol; suramin in mixtures with plasma (0.5 ml) or trypanosomes (200 mg wet wt.).
Assuntos
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Base de dados: MEDLINE Assunto principal: Suramina / Trypanosoma brucei brucei / Tripanossomíase Africana Limite: Animals Idioma: En Revista: Mol Biochem Parasitol Ano de publicação: 1980 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Suramina / Trypanosoma brucei brucei / Tripanossomíase Africana Limite: Animals Idioma: En Revista: Mol Biochem Parasitol Ano de publicação: 1980 Tipo de documento: Article