Serial use of aprotinin and incidence of allergic reactions.
Curr Med Res Opin
; 8(8): 559-61, 1983.
Article
em En
| MEDLINE
| ID: mdl-6197239
ABSTRACT
Allergic reactions to aprotinin, a polypeptide, have been reported on several occasions. A survey of 136 courses of aprotinin, given to patients with gastric cancer as a protease inhibitor, has shown an incidence of less than 1% of acute anaphylaxis and a similar incidence of minor allergic responses. Two cases of acute allergic responses are described. Fifteen patients received repeated courses of aprotinin at 6-weekly intervals and no allergic phenomena were detected. Provided patients are challenged intra-dermally or with eye drops before each course, it is considered that aprotinin is safe to use in repeated fashion.
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Base de dados:
MEDLINE
Assunto principal:
Aprotinina
/
Hipersensibilidade a Drogas
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Risk_factors_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Curr Med Res Opin
Ano de publicação:
1983
Tipo de documento:
Article