Suppression of natural killer cell activity by Friend murine leukemia virus.
J Natl Cancer Inst
; 72(6): 1349-56, 1984 Jun.
Article
em En
| MEDLINE
| ID: mdl-6202923
ABSTRACT
BALB/c mice infected with Friend murine leukemia virus (F-MuLV) evinced a decreased natural killer (NK) cell activity to susceptible target cells. This suppression increased as the interval between infection and assay was lengthened. The decrease in NK activity due to F-MuLV infection was partially reversible when spleen cells were pretreated with interferon before the cytolytic assay. The ability of F-MuLV-infected splenocytes to bind to target cells was unaltered, indicating that the defect was in the lytic phase of NK cytolysis. When mixed with uninfected spleen cells, F-MuLV-infected splenocytes suppressed their NK cell activity. This suppression was associated with a nylon wool-adherent cell population in the F-MuLV-infected spleens.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Vírus da Leucemia Murina de Friend
/
Tolerância Imunológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Natl Cancer Inst
Ano de publicação:
1984
Tipo de documento:
Article