Morphine and nigrostriatal function in the rat and mouse: the role of nigral and striatal opiate receptors.
Neuropharmacology
; 21(12): 1305-10, 1982 Dec.
Article
em En
| MEDLINE
| ID: mdl-6296716
ABSTRACT
Using local injections of drugs and hemisection experiments, a comparison was made of the actions of morphine on the dopaminergic nigrostriatal system of the rat and mouse. In the rat, morphine appeared to act exclusively at presynaptic opiate receptors on dopaminergic nerve endings in the striatum. Activation of these receptors resulted in enhanced dopamine synthesis but with no associated increase in dopamine release. In the mouse, morphine acted at the level of the substantia nigra to enhance both striatal dopamine synthesis and release. The exact localization of these receptors in the substantia nigra remains to be determined.
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Base de dados:
MEDLINE
Assunto principal:
Substância Negra
/
Receptores Opioides
/
Corpo Estriado
/
Morfina
Limite:
Animals
Idioma:
En
Revista:
Neuropharmacology
Ano de publicação:
1982
Tipo de documento:
Article