Effectiveness of allopurinol against Leishmania braziliensis panamensis in Aotus trivirgatus.
Am J Trop Med Hyg
; 32(1): 46-50, 1983 Jan.
Article
em En
| MEDLINE
| ID: mdl-6297325
ABSTRACT
Orally administered allopurinol at 50 mg/kg for 21 days showed pronounced antileishmanial activity against experimentally induced lesions of Leishmania braziliensis panamensis on the nose of Panamanian Aotus trivirgatus monkeys, with complete healing in 4 of 5, although parasitologic cure was achieved in only 2 of 5. The same total daily dose of drug, given in a divided dose twice daily, resulted in complete healing in all 5, and parasitologic cure in 4 of 5 animals. Standard treatment controls receiving 40 mg/kg of antimony stibogluconate intramuscularly for 15 days showed healing in 4 of 5 monkeys. It is not known if a similar level of effectiveness would result with this dose of allopurinol in humans, since Aotus may have a different pattern of metabolic conversion of the drug to the more active riboside.
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Base de dados:
MEDLINE
Assunto principal:
Leishmaniose
/
Alopurinol
Limite:
Animals
País/Região como assunto:
America central
/
America do sul
/
Brasil
/
Panama
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
1983
Tipo de documento:
Article