Age-related changes of benzodiazepine and GABA binding sites in the rat retina.
Neurobiol Aging
; 3(3): 227-31, 1982.
Article
em En
| MEDLINE
| ID: mdl-6298648
ABSTRACT
The changes in the number and sensitivity of benzodiazepine and GABA binding sites in the rat retina during postnatal development, adulthood and ageing and their functional relationship at different ages have been studied. Data indicate an increase in the total number of both GABA and benzodiazepine binding sites with age. In contrast, the activation of retinal benzodiazepine receptor binding by GABA is significantly reduced in aged rats with respect to young adult and newborn rats. Moreover, the activation of retinal benzodiazepine receptor binding induced by dark exposure of the animals is present in young adult rats but is lost in aged rats. These results suggest that in the retina of aged rats there is an increase of GABA and benzodiazepine receptors which have lost their functional connection.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Envelhecimento
/
Receptores de Superfície Celular
Limite:
Animals
Idioma:
En
Revista:
Neurobiol Aging
Ano de publicação:
1982
Tipo de documento:
Article