Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats.
Science
; 220(4594): 323-5, 1983 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-6301005
ABSTRACT
Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D-myo-inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Parassimpatomiméticos
/
Convulsões
/
Transtornos Relacionados ao Uso de Substâncias
/
Fosfatos de Inositol
/
Lítio
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article