Calcitonin as an indicator of the response of human small cell carcinoma of the lung cells to drugs and radiation.
Cancer Res
; 44(3): 949-54, 1984 Mar.
Article
em En
| MEDLINE
| ID: mdl-6318988
ABSTRACT
A calcitonin (CT)-producing cell line (DMS53) established from human small cell carcinoma of the lung was grown as three-dimensional multicellular spheroids in spinner culture or on agar in multiwells, and as tumors in nude (athymic) mice. CT release into the media was directly proportional to spheroid volume. The response of these cells following exposures to X-irradiation, Adriamycin, or diazoacetylcholine iodide was assessed by monitoring levels of CT released into the media by individual spheroids. Levels of CT in the blood of nude mice bearing DMS53 xenografts were directly proportional to tumor volume and decreased proportionally with tumor response to X-irradiation and cisplatin treatment. These results suggest that the DMS53 spheroid and xenograft models may be useful systems to monitor responses to therapy utilizing CT as an indicator of tumor burden.
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Base de dados:
MEDLINE
Assunto principal:
Calcitonina
/
Cisplatino
/
Carcinoma de Células Pequenas
/
Neoplasias Pulmonares
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1984
Tipo de documento:
Article