Immunobiology of Langerhans' cells migrating into aural cholesteatomas.
Otolaryngol Head Neck Surg
; 92(1): 1-6, 1984 Feb.
Article
em En
| MEDLINE
| ID: mdl-6422403
ABSTRACT
Immunohistochemical and submicroscopic analyses of human cholesteatoma matrices reveal the presence of Langerhans' cells and T lymphocytes. Through cell-to-cell interaction, Langerhans' cells probably play a key role in skin-related disorders, including cholesteatomas. They originate from a mobile cell population of monocyte origin and migrate into and out of the body's lining. Their custodial function is always carried out in close relation with T lymphocytes. Various monoclonal antibodies directed against Langerhans' cell and T lymphocyte membrane receptors reveal the presence of these cell populations in cholesteatoma matrices but not in the tympanic membrane. Langerhans' cell and T cell traffic through cholesteatomas are discussed in relation to the pathogenesis, natural course, and recurrence rate of cholesteatomas. Through immunopathologic evaluation the clinical aggressiveness of a cholesteatoma will probably become predictable. Medical manipulation of Langerhans' cell and T cell functions- as an adjuvant to surgery - may have consequences for the future handling of cholesteatomas.
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Base de dados:
MEDLINE
Assunto principal:
Células de Langerhans
/
Colesteatoma
Limite:
Adolescent
/
Adult
/
Child
/
Humans
/
Middle aged
Idioma:
En
Revista:
Otolaryngol Head Neck Surg
Ano de publicação:
1984
Tipo de documento:
Article