An illness severity score for multiple sclerosis.
Neurology
; 34(10): 1343-7, 1984 Oct.
Article
em En
| MEDLINE
| ID: mdl-6541306
ABSTRACT
A single score is desirable for evaluating progression in clinical trials of MS therapy. Our objective was to develop a more sensitive scoring that would reflect clinical assessment of relative severity of disability. An Illness Severity Score (ISS) was developed as a sum of weights corresponding to ratings of Kurtzke Disability Status Scale and Functional Systems Scales and phase of illness. Weights were computed from clinical comparison of pairs of patients. The score was standardized to have mean 50 and standard deviation 10 in a single clinic population. Score reproducibility (correlation = 0.93) was evaluated by two independent scorings of several patients. The ISS was satisfactory as the primary assessment in a small-scale clinical trial.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Esclerose Múltipla
/
Exame Neurológico
Limite:
Humans
Idioma:
En
Revista:
Neurology
Ano de publicação:
1984
Tipo de documento:
Article