Activation of heparin cofactor II by heparin and dermatan sulfate.
Nouv Rev Fr Hematol (1978)
; 26(4): 233-7, 1984.
Article
em En
| MEDLINE
| ID: mdl-6548014
ABSTRACT
Heparin cofactor II is a glycoprotein present in human plasma at a concentration of approximately 1.2 microM. It inhibits thrombin by forming a stable, 11 complex with the protease. The rate of complex formation is increased approximately 1,000-fold by heparin or dermatan sulfate. Heparin cofactor II appears to be the only thrombin inhibitor in plasma that can be activated by dermatan sulfate. Platelet factor 4 abolishes the activation of heparin cofactor II by dermatan sulfate, but plasma histidine-rich glycoprotein does not. Heparin cofactor II is activated by dermatan sulfate oligosaccharides that are at least 12-14 sugar residues in length and contain a high-affinity binding site for the inhibitor protein.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas
/
Heparina
/
Condroitina
/
Dermatan Sulfato
Limite:
Humans
Idioma:
En
Revista:
Nouv Rev Fr Hematol (1978)
Ano de publicação:
1984
Tipo de documento:
Article