Depressive symptoms in chronic schizophrenic patients after withdrawal of long-acting neuroleptics.
J Clin Psychiatry
; 44(10): 369-71, 1983 Oct.
Article
em En
| MEDLINE
| ID: mdl-6643398
ABSTRACT
A double-blind randomized investigation compared withdrawal (placebo) with continued use of long-acting neuroleptics (fluphenazine decanoate or flupenthixol decanoate) in 41 chronic schizophrenic outpatients. After 6 weeks there was a tendency toward higher depressive scores in the placebo group, a difference which became statistically significant (p less than .05) at week 24. These results do not support earlier observations that neuroleptic drugs cause depression. Further analyses of the data indicated that depressive symptomatology could be an early sign of relapse.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Síndrome de Abstinência a Substâncias
/
Tioxantenos
/
Tranquilizantes
/
Transtorno Depressivo
/
Flupentixol
/
Flufenazina
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Psychiatry
Ano de publicação:
1983
Tipo de documento:
Article