Ultrastructural changes in the dog liver cell after isolated liver perfusion with various cytotoxins.
Recent Results Cancer Res
; 86: 103-9, 1983.
Article
em En
| MEDLINE
| ID: mdl-6685901
ABSTRACT
Following isolated liver perfusion with different cytotoxins - 5-fluorouracil (5-FU), methotrexate (MTX), dacarbazine (DTIC) cis-platinum (cis-PT) - liver tissue of dogs was examined with the electron microscope (a) directly after the perfusion and (b) after a survival time of 4 weeks (5-FU and DTIC). Acute disintegration of the granular endoplasmic reticulum and depletion of the glycogen stores occurred after perfusion with 5-FU, MTX, and DTIC, while cis-PT induced disintegration of the granular endoplasmic reticulum accompanied by an accumulation of glycogen. Four weeks after perfusion with DTIC signs of remarkably increased cellular activity were observed, while 4 weeks after perfusion with 5-FU the parenchymal liver cells revealed a well-balanced and moderate recovery of the cellular structures.
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Base de dados:
MEDLINE
Assunto principal:
Quimioterapia do Câncer por Perfusão Regional
/
Fígado
/
Neoplasias Hepáticas
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Recent Results Cancer Res
Ano de publicação:
1983
Tipo de documento:
Article