The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4.
Science
; 223(4631): 71-4, 1984 Jan 06.
Article
em En
| MEDLINE
| ID: mdl-6691137
ABSTRACT
Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.
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Base de dados:
MEDLINE
Assunto principal:
Oncogenes
/
Cromossomos Humanos 1-3
/
Cromossomos Humanos 4-5
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Science
Ano de publicação:
1984
Tipo de documento:
Article