IgE in the cerebrospinal fluid.
J Neuroimmunol
; 6(5): 319-24, 1984 Aug.
Article
em En
| MEDLINE
| ID: mdl-6746896
ABSTRACT
The level of IgE in the cerebrospinal fluid (CSF) was determined by particle counting immunoassay. With a limit of sensitivity of 0.2 IU/ml, this immunoglobulin was detected neither in CSF of non-neurological patients (n = 27) nor of patients with sciatica (n = 13). IgE was present in samples from some patients with either multiple sclerosis (MS) or various infections of the central nervous system. In these cases, an IgE index [CSF IgE/serum IgE CSF albumin/serum albumin] was calculated as 0.29 (SD 0.12). This value is not abnormal as the mean IgG and monomeric IgA indices are 0.45 and 0.34, respectively. Therefore, the IgE detected in most of the CSF samples was not locally produced. However, most patients with tuberculous meningitis had clearly an increased IgE index suggesting a local biosynthesis, but we failed to detect any IgE antibody activity against purified protein derivatives.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina E
Limite:
Humans
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1984
Tipo de documento:
Article