Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas.
Psychopharmacology (Berl)
; 67(3): 261-4, 1980.
Article
em En
| MEDLINE
| ID: mdl-6770406
ABSTRACT
Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Etanol
/
Ácido gama-Aminobutírico
Limite:
Animals
Idioma:
En
Revista:
Psychopharmacology (Berl)
Ano de publicação:
1980
Tipo de documento:
Article