B cell helper factors. I. Requirement for both interleukin 2 and another 40,000 mol wt factor.
J Exp Med
; 154(5): 1681-93, 1981 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-6795304
ABSTRACT
A helper factor(s) distinct from interleukin 2 (IL-2) was shown to be present in the concanavalin A-stimulated supernatant of normal mouse spleen cells (normal Con A Sn). Spleen cells thoroughly depleted of T cells required both IL-2 and this factor to produce antibody-secreting cells in response to sheep erythrocytes, although in the presence of IL-2 and a few T cells the requirement for the factor was less apparent. The factor had an apparent approximately 40,000 mol wt. The factor was found in normal Con A Sn that had been depleted of IL-2 by absorption with IL-2-dependent T cells and was absent from Con A-stimulated supernatants of the IL-2-producing T cell hybridoma, FS6-14.13. These results indicate that multiple helper factors control the B cell response to antigen and that IL-2, in addition to its T cell growth promoting activity, plays a direct role in B cell responses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Proteínas
/
Linfocinas
/
Interleucina-2
Limite:
Animals
Idioma:
En
Revista:
J Exp Med
Ano de publicação:
1981
Tipo de documento:
Article