Formation of an adenine-thymine photoadduct in the deoxydinucleoside monophosphate d(TpA) and in DNA.
Science
; 220(4598): 723-5, 1983 May 13.
Article
em En
| MEDLINE
| ID: mdl-6836308
ABSTRACT
A photoadduct is formed between the adenine (A) and thymine (T) bases of the deoxydinucleoside monophosphate d(TpA) when it is irradiated at 254 nanometers in aqueous solution. Treatment of the photoadduct with acid converts it specifically into a fluorescent hydrolysis product, C7H7N3O, incorporating the position-8 carbon of adenine and the methyl group of thymine. Isolation of the fluorescent hydrolysis product from acid hydrolyzates of oligo- and polydeoxyribonucleotides has shown that the photoadduct is formed by ultraviolet irradiation of d(pTpA), d(TpApT), d(TpApTpA), poly(dA-dT), and both single- and double-stranded DNA.
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Base de dados:
MEDLINE
Assunto principal:
Timidina
/
Nucleotídeos de Timina
/
DNA
/
Adenina
Idioma:
En
Revista:
Science
Ano de publicação:
1983
Tipo de documento:
Article