Does the antitumoral activity of platinum (IV) derivatives result from their in vivo reduction?
Tumori
; 69(1): 31-6, 1983 Feb 28.
Article
em En
| MEDLINE
| ID: mdl-6836747
ABSTRACT
The antitumoral activity of some octahedral platinum(IV) and square-planar platinum(II) derivatives against Yoshida ascites tumor in the rat is reported. It is shown that only those octahedral platinum(IV) complexes which give active reduction products are active. These results support the hypothesis that the antitumor activity of octahedral complexes involves activation by in vivo reduction. Anticancer drugs functioning by this mechanism may be preferentially toxic to or may localize in hypoxic areas of tumors.
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Base de dados:
MEDLINE
Assunto principal:
Platina
/
Neoplasias Experimentais
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
Tumori
Ano de publicação:
1983
Tipo de documento:
Article