Rebound insomnia: a new clinical syndrome.
Science
; 201(4360): 1039-41, 1978 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-684426
ABSTRACT
Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Abstinência a Substâncias
/
Benzodiazepinas
/
Hipnóticos e Sedativos
/
Distúrbios do Início e da Manutenção do Sono
Limite:
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
1978
Tipo de documento:
Article