Early presence of phospholamban in developing a chick heart.
FEBS Lett
; 155(2): 326-30, 1983 May 08.
Article
em En
| MEDLINE
| ID: mdl-6852244
ABSTRACT
Phosphorylation of phospholamban and development of reticular Ca2+ transport were studied in crude membrane preparations of embryonic, newborn and adult chick heart. Maximal phosphorylation of phospholamban by added catalytic subunit of cyclic AMP-dependent protein kinase increases from embryonic day 4-15. It decreases with further development. In the same membrane preparations active Ca2+-uptake into vesicles of sarcoplasmic reticulum rises from day 4-7 and decreases then slightly until day 20. A several-fold increase in Ca2+-transport activity occurs at the time of hatching. The data indicate separate genetic control for synthesis of phospholamban and sarcoplasmic reticulum Ca2+-ATPase.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao Cálcio
/
Coração
/
Miocárdio
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1983
Tipo de documento:
Article