Early effect of ledakrin -- a nitro-derivative of acridine -- on cell membrane.
Acta Physiol Pol
; 31(1): 81-91, 1980.
Article
em En
| MEDLINE
| ID: mdl-6966462
ABSTRACT
Ledakrin effect on the bioelectrical parameters of sodium ion transport (potential difference -- PD and short-circuit current -- SSC) and on Na22 transport across frog (R. esculenta) skin was studied in vitro. Ledakrin induced a biphasic action, after a phase of increase of PD, SCC and sodium flux the transport of sodium ions decreased gradually. The effect of this nitro-derivative of acridine was compared with that of Amiloride. When both these agents were given simultaneously only one phase developed, that is inhibition of sodium ion transport. In both situations there was a significant stimulation of outflux. The obtained results suggest that the external apical cell membrane of epithelial cells is the site of action of Ledakrin.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Acridinas
/
Permeabilidade da Membrana Celular
/
Nitracrina
Limite:
Animals
Idioma:
En
Revista:
Acta Physiol Pol
Ano de publicação:
1980
Tipo de documento:
Article