Stimulated platelet aggregation, thromboxane B2 formation and platelet sensitivity to prostacyclin - a critical evaluation.
Thromb Haemost
; 45(3): 204-7, 1981 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-7025338
ABSTRACT
Platelets have been implicated in the development of atherosclerotic and thrombotic vascular diseases. Evaluation of platelet aggregation in relation to endogenously formed compounds which affect platelet function may provide information of clinical and pharmacological relevance. We describe a method in which thromboxane B2 (TXB2) formation was analyzed following stimulation of platelet-rich plasma (PRP) with ADP, 1-epinephrine, collagen, and arachidonic acid. In addition, we determined platelet sensitivity to prostacyclin following ADP- and collagen-induced platelet aggregation. The parameters under study were found to depend on the platelet count in PRP, on the type and dose of the aggregating agent used, and on the test time after blood sampling. By standardization of these variables, a reliable method was established which can be used in clinical and pharmacological trials.
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Base de dados:
MEDLINE
Assunto principal:
Tromboxano B2
/
Plaquetas
/
Agregação Plaquetária
/
Prostaglandinas
/
Tromboxanos
/
Epoprostenol
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Humans
Idioma:
En
Revista:
Thromb Haemost
Ano de publicação:
1981
Tipo de documento:
Article