Genetic analysis of an N-ethyl-N-nitrosourea-induced mutation at the hemoglobin beta-chain locus in mice.
Mutat Res
; 104(4-5): 317-21, 1982.
Article
em En
| MEDLINE
| ID: mdl-7110170
ABSTRACT
The specific-locus test was performed with N-ethyl-N-nitrosourea (ENU) on spermatogonia of mice by using visible loci and a hemoglobin beta-chain (Hbb) locus. Male wild-type (C3Hf/He) mice were injected intraperitoneally with ENU. 8 weeks after injection, these males were mated with tester strain females (PW). 9 visible mutants and the 1 Hbb locus mutant were obtained. This Hbb locus mutation was heritable and viable under homozygous conditions, suggesting that it might have resulted from events at the molecular level.
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Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas
/
Etilnitrosoureia
/
Mutação
/
Compostos de Nitrosoureia
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1982
Tipo de documento:
Article