Intrauterine delivery of indomethacin from a silastic device: effect on the preimplantation embryo and implantation.
Contraception
; 26(1): 97-107, 1982 Jul.
Article
em En
| MEDLINE
| ID: mdl-7128139
ABSTRACT
Plain silastic IUDs and those incorporating 3.3% w/w of indomethacin were fitted into one uterine horn of adult rats. After a period of 3 weeks, animals were mated and studied for the effects these devices had on the preimplantation embryo, Pontamine Blue Reaction and implantation rates. The indomethacin-loaded devices had no observable effect on ovulation, fertilization or ovum transport. In the horns bearing an indomethacin device, the intrauterine degeneration of preimplantation embryos on Day 5 was not as rapid as was found for the horns bearing plain devices. On Day 6 of pregnancy, Pontamine Blue Reaction sites were virtually absent in the horns bearing either type of device, as were the numbers of normal-sized implants on Days 9 or 10. There was a slight increase in the numbers of abnormal, small implants in horns with indomethacin devices.
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Base de dados:
MEDLINE
Assunto principal:
Implantação do Embrião
/
Indometacina
/
Desenvolvimento Embrionário
/
Dispositivos Intrauterinos
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
Contraception
Ano de publicação:
1982
Tipo de documento:
Article