Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.
Cancer Res
; 38(12): 4496-8, 1978 Dec.
Article
em En
| MEDLINE
| ID: mdl-719633
ABSTRACT
Administration of the antioxidant 2(3)-tert-butyl-4-hydroxyanisole (BHA) in the diet caused a marked increase in the specific activity of epoxide hydratase (EC 4.2.1.63) in hepatic microsomes of CD-1 mice. The increases in epoxide hydratase activities produced by BHA were far greater (11-fold) than were those produced by the administration of well-known enzyme inducers such as 3-methylcholanthrene, phenobarbital, and Aroclor 1254 (2- to 3-fold). The near-maximal increase in epoxide hydratase activity was observed after feeding of the BHA diet for 3 days. When BHA was administered by gastric intubation, the level of increase was only 75% of that attained by feeding BHA in the diet. The increase in epoxide hydratase activity produced by BHA treatment of Sprague-Dawley rats was not as pronounced (less than 3-fold) as that observed in CD-1 mice.
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Base de dados:
MEDLINE
Assunto principal:
Hidroxianisol Butilado
/
Microssomos Hepáticos
/
Epóxido Hidrolases
/
Anisóis
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1978
Tipo de documento:
Article