Primary pituitary aspergillosis responding to transsphenoidal surgery and combined therapy with amphotericin-B and 5-fluorocytosine: case report.
J Neurosurg
; 54(6): 839-41, 1981 Jun.
Article
em En
| MEDLINE
| ID: mdl-7241195
ABSTRACT
Pituitary abscess is an unusual cause of sella turcica enlargement. Because its presentation closely mimics that of a pituitary tumor, the condition is seldom recognized preoperatively. Most cases have been of bacterial etiology; however, a single patient with a primary mycotic pituitary abscess secondary to Aspergillus species has been reported. That patient died of diffuse Aspergillus meningoencephalitis following a transfrontal craniotomy. In the present case, a woman with primary pituitary aspergillosis survived her infection with virtually intact pituitary function following a transsphenoidal approach which avoided contamination of cerebrospinal fluid. Postoperative amphotericin-B and 5-fluorocytosine therapy probably contributed greatly to her survival. Factors that should alert the clinician to the presence of a pituitary abscess in a patient with sella turcica enlargement are prior episodes of meningitis, sinusitis, or cerebrospinal fluid abnormalities, including pleocytosis, depressed glucose, and elevated protein.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Doenças da Hipófise
/
Aspergilose
/
Abscesso Encefálico
/
Anfotericina B
/
Citosina
/
Flucitosina
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
J Neurosurg
Ano de publicação:
1981
Tipo de documento:
Article