Effect of diet on excretion of estrogens in pre- and postmenopausal women.
Cancer Res
; 41(9 Pt 2): 3771-3, 1981 Sep.
Article
em En
| MEDLINE
| ID: mdl-7260944
ABSTRACT
Fecal, urinary, and plasma estrogens and plasma androgens were studied in healthy pre- and postmenopausal vegetarian and omnivorous women. Dietary histories of the subjects revealed that omnivores consumed a higher percentage of total protein and fat from animal sources. The total 72-hr fecal excretion as measured by dry weight was higher for vegetarians. Preliminary results indicate that vegetarian women excrete 2 to 3 times more estrogens in feces than do omnivores and that omnivores have about 50% higher mean plasma level of unconjugated estrone and estradiol than vegetarians. Estriol-3-glucuronide, a compound that is formed upon reabsorption of free estriol from the intestine, is found in lower concentrations in the urine of vegetarians. These data suggest that in vegetarians a greater amount of the biliary estrogens escape reabsorption and are excreted with the feces. The differences in estrogen metabolism may explain the lower incidence of breast cancer in vegetarian women.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Menopausa
/
Dieta
/
Estrogênios
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1981
Tipo de documento:
Article