Recovery of the hepatic drug-metabolizing capacity in mice infected with Schistosoma mansoni following curative chemotherapy with the schistosomicide 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540).

ABSTRACT

Treatment of mice infected with Schistosoma mansoni with a single oral dose of formulated 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540) restored the capacity of the liver of these animals to metabolize certain drugs. Full recovery required 35-40 weeks. Administration of CGP 4540 to non-infected animals produced no significant changes in the activities of some hepatic drug-metabolizing enzymes.