Recovery of the hepatic drug-metabolizing capacity in mice infected with Schistosoma mansoni following curative chemotherapy with the schistosomicide 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540).
Am J Trop Med Hyg
; 27(6): 1188-91, 1978 Nov.
Article
em En
| MEDLINE
| ID: mdl-727323
ABSTRACT
Treatment of mice infected with Schistosoma mansoni with a single oral dose of formulated 4-isothiocyano-4'-nitro-diphenylamine (CGP 4540) restored the capacity of the liver of these animals to metabolize certain drugs. Full recovery required 35-40 weeks. Administration of CGP 4540 to non-infected animals produced no significant changes in the activities of some hepatic drug-metabolizing enzymes.
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Base de dados:
MEDLINE
Assunto principal:
Esquistossomose
/
Esquistossomicidas
/
Tiocianatos
/
Preparações Farmacêuticas
/
Difenilamina
/
Fígado
/
Compostos de Anilina
Limite:
Animals
Idioma:
En
Revista:
Am J Trop Med Hyg
Ano de publicação:
1978
Tipo de documento:
Article