Structural and biochemical changes in rat cerebral cortex after neonatal 6-hydroxydopamine administration.
Anat Embryol (Berl)
; 159(3): 245-55, 1980.
Article
em En
| MEDLINE
| ID: mdl-7457904
ABSTRACT
Newborn rats received an intracisternal injection of 6-hydroxydopamine (100 micrograms) within 16 h after birth. Treatment effects upon noradrenaline uptake (with or without desmethylimipramine pre-incubation), endogenous noradrenaline, dopamine, and serotonin were biochemically assayed. Noradrenaline uptake and endogenous noradrenaline content were permanently reduced to less than 5% of control values. Reduction of endogenous dopamine content was less marked at day 60, values were about 40% of controls. Serotonin content remained unaffected. Cell density countings in postnatal day 15 temporal cortex revealed an about 16% reduction in layers II and III of treated animals. These modifications of cortical geometry were discussed with reference to measurements of cortical thickness and ultrastructural observations on postnatal days 2, 5 and 15. Both supranormal involution and growth processes might result from the neurotoxin treatment. Whereas some of the degeneration processes might be due o general cytotoxic effects, this is less likely for the supranormal growth processes.
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Base de dados:
MEDLINE
Assunto principal:
Córtex Cerebral
/
Hidroxidopaminas
Limite:
Animals
Idioma:
En
Revista:
Anat Embryol (Berl)
Ano de publicação:
1980
Tipo de documento:
Article