Low diagnostic yield of sural nerve biopsy in patients with peripheral neuropathy and primary amyloidosis.
J Neurol Sci
; 120(1): 60-3, 1993 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-7507161
ABSTRACT
Patients with primary amyloidosis may develop peripheral neuropathy as an early feature. Sural nerve biopsy is reported to be a sensitive method for diagnosing amyloidosis in such patients. We identified nine patients, ultimately diagnosed as having amyloidosis, who were referred for peripheral neuropathy of undetermined etiology. In six, a sural nerve biopsy demonstrated no amyloid. Subsequent examination of other tissue or of the contralateral sural nerve eventually resulted in the correct diagnosis. We conclude that sural nerve biopsy may be less sensitive than previously believed for the diagnosis of amyloidosis in patients with peripheral neuropathy secondary to amyloid. When the clinical suspicion of amyloidosis is high, a nondiagnostic sural nerve biopsy should not discourage the performance of further investigative studies.
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Base de dados:
MEDLINE
Assunto principal:
Nervo Sural
/
Doenças do Sistema Nervoso Periférico
/
Amiloidose
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Neurol Sci
Ano de publicação:
1993
Tipo de documento:
Article