Genotoxicity evaluation of pyrazinamide in mice.
Mutat Res
; 321(1-2): 1-5, 1994 Apr.
Article
em En
| MEDLINE
| ID: mdl-7510837
ABSTRACT
Pyrazinamide, an antituberculosis drug, was investigated for genotoxicity in mice, an in vivo rodent system. Three doses (125, 250 and 500 mg/kg bw corresponding to 5, 10 and 20 times the therapeutic dose respectively) were tested. The mitotic index and the frequency of chromosomal aberrations were analysed at three sample times (3, 6 and 24 h) after a single intraperitoneal treatment. The frequency of sperm shape abnormalities was also examined. The mitotic index showed a decrease in drug-treated animals compared with that recorded in the control set. The cells with chromosomal aberrations ranged from 4% to 8%. The maximum frequency of aberrations was found at the 3-h sample time. The frequency of sperm shape abnormalities showed a dose-related increase. These observations suggest pyrazinamide to be a weak genotoxicant at the doses tested.
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Base de dados:
MEDLINE
Assunto principal:
Pirazinamida
/
Espermatozoides
/
Aberrações Cromossômicas
/
Mutagênicos
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Mutat Res
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Índia