The pharmacokinetics of risperidone in humans: a summary.
J Clin Psychiatry
; 55 Suppl: 13-7, 1994 May.
Article
em En
| MEDLINE
| ID: mdl-7520903
ABSTRACT
Risperidone is rapidly and completely absorbed after oral administration; less than 1% is excreted unchanged in the feces. The principal metabolite was found to be 9-hydroxyrisperidone. Hydroxylation of risperidone is subject to the same genetic polymorphism as debrisoquine and dextromethorphan. In poor metabolizers the half-life of risperidone was about 19 hours compared with about 3 hours in extensive metabolizers. However, becuase the pharmacology of 9-hydroxyrisperidone is very similar to that of risperidone, the half-life for the "active fraction" (risperidone +9-hydroxyrisperidone) was found to be approximately 20 hours in extensive and poor metabolizers. We found that risperidone exhibited linear elimination kinetics and that steady state was reached within 1 day for risperidone and within 5 days for the active fraction.
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Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Antipsicóticos
/
Isoxazóis
Limite:
Aged
/
Animals
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Psychiatry
Ano de publicação:
1994
Tipo de documento:
Article
País de afiliação:
Bélgica