Adhesion molecules in hematopoietic cells.
Blood Cells
; 20(1): 25-44, 1994.
Article
em En
| MEDLINE
| ID: mdl-7527678
ABSTRACT
Interaction with stromal cells is known to be crucial for growth and differentiation of hematopoietic cells. To characterize adhesion molecules involved in this interaction, we examined adhesion of a panel of lymphoid, myeloid, and mast cell lines with stromal cells. We found that very late antigen-4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) were major adhesion molecules in lymphoid and myeloid cells, whereas myeloma cells adhered to stromal cells through hyaluronate. We investigated regulation of VLA-4 during differentiation of myeloid cells using a neutrophil precursor cell line, L-G3. Differentiation of neutrophils induced by granulocyte colony-stimulating factor was accompanied with down-regulation of VLA-4. Induced L-G3 cells adhered to stromal cells in proportion to the expression of VLA-4. Mast cells used two mechanisms to adhere to fibroblasts and stromal cells. They adhered to fibronectin through VLA-5 when stimulated with steel factor and also directly to membrane-anchored steel factor through c-kit.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Hematopoéticas
/
Moléculas de Adesão Celular
Limite:
Animals
Idioma:
En
Revista:
Blood Cells
Ano de publicação:
1994
Tipo de documento:
Article