Expression of B7-1 by highly metastatic mouse T lymphomas induces optimal natural killer cell-mediated cytotoxicity.
Cancer Res
; 55(13): 2730-3, 1995 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-7540948
ABSTRACT
The interaction between B7-1 and CD28 provides costimulatory signals not only for T cells but also for natural killer (NK) cells. Highly metastatic mouse T lymphoma cells (BW-Li) can escape from NK cell-mediated killing by expressing H-2Dk molecules that negatively regulate NK lytic activity. We have analyzed whether B7-1CD28 overrules the MHC class I-mediated inactivation of NK cells by transfecting BW-Li with the gene coding for B7-1. Expression of B7-1 rendered BW-Li cells sensitive toward NK cells. The experimental metastatic capacity of the B7-1 transfectants was drastically reduced in both syngeneic AKR and SCID mice but could be restored in SCID-bg mice. These results provide direct evidence that B7-1 expression leads to NK-mediated elimination of metastasizing, NK-resistant tumor cells.
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Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Linfoma de Células T
/
Antígeno B7-1
Limite:
Animals
Idioma:
En
Revista:
Cancer Res
Ano de publicação:
1995
Tipo de documento:
Article